Osteoarthritis Breakthrough: 15-PGDH Protein

Osteoarthritis Breakthrough: 15-pgdh Protein

View January 2026 Crrent Affairs

Context: Researchers at Stanford University identified a "gerozyme" (aging enzyme) called 15-PGDH as a master regulator of cartilage loss.

  • The Discovery: As we age, 15-PGDH levels increase, breaking down the molecules that repair cartilage.
  • New Treatment: By using an inhibitor to block this protein, scientists successfully regrew healthy articular cartilage in mice.
  • Future Impact: This offers a potential alternative to knee and hip replacements, shifting the focus from "pain management" to "tissue regeneration."
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