Context: Researchers at Stanford University identified a "gerozyme" (aging enzyme) called 15-PGDH as a master regulator of cartilage loss.
- The Discovery: As we age, 15-PGDH levels increase, breaking down the molecules that repair cartilage.
- New Treatment: By using an inhibitor to block this protein, scientists successfully regrew healthy articular cartilage in mice.
- Future Impact: This offers a potential alternative to knee and hip replacements, shifting the focus from "pain management" to "tissue regeneration."
UPSC - 2027 - Prelims cum Mains - Foundation Course / Orientation on 08-03-2026 
